Safe vs. Unsafe
Baserunners are notorious for leading off from a base in hopes of getting an early start at advancing to the next base. If a baserunner is overconfident in his leadoff, he may be susceptible to a pickoff.
IMPORTANT: Depending on the level of play and the rules of the league, leading off might not be allowed. Please refer to your league's rulebook for more information.
1st Base Pickoffs
Pickoffs most often occur at first base. Before a pitch, the pitcher will quickly throw the kickball to the first baseman, who tries to tag out the baserunner with the kickball. If the first baseman tags the runner before the runner touches first base, the runner is out and the pickoff is successful.