The game is not played at the stadium of the home team, but at a set location chosen at the beginning of the season. However, there is a home and away team, which is alternated between conferences every year. Being home or away only affects the color of the jerseys that can be worn.
There are also differences in how the game is broadcasted, stretching the game out to allow for various entertainment pieces.
During the Super Bowl commercials run longer than in the NFL regular season. That is to allow companies to pay large sums of money to have their advertisements run on the large stage the Super Bowl provides.
Just like commercials the Super Bowl halftime is longer than the regular season's. The standard 13 minute halftime is doubled to be 30 minutes long, which allows for a live performance by a music group.
Overtime rules also vary slightly from the regular season. In the regular season ties are a possibility if after one overtime period the teams are still level. However, teams may not tie in the Super Bowl and the game must end with a winning team. In response, the NFL added an overtime rule stating that there would be unlimited overtime periods. The rest of the overtime rules are kept, the only difference is the game goes until a team scores.
In order to make it to the Super Bowl a team must win its conference. Each conference (AFC and NFC) send one representative that wins their playoff bracket to the Super Bowl. To be the winner, a team must first qualify for the playoffs. Each division winner, and two more teams with the best record (wild cards) enter the conference bracket. There are three rounds a team must advance through to win the conference and make it to the Super Bowl.