If a fantasy league has an odd number of teams, there will be at least one week where your team has no opponent, meaning your record will not change and your points scored will not count.
The more important bye weeks are the ones for the actual players. The first step to setting your lineup each week is to take note of which players are injured or out, but then it is assessing your bye week situation. Obviously players cannot play on their bye week, so your starting spots must be filled with reserves or added players in order to give you the best chance at victory.
Dilemmas with player bye weeks are an avoidable for fantasy owner and start all the way at the draft. You must be cognizant of the bye weeks of the players you are drafting so that you do not have many players with the same bye week, which would essentially forfeit that week.
The most important positions to think about are quarterback and running back during the draft. There may not be many quality players available at each position, so drafting players who can replace your starters is a key to success.
In terms of defenses and kickers, it is not worth it to have multiple of the positions on your roster, so when their bye weeks roll around the best strategy is to drop them for another player and then attempt to claim them off waivers the following week. If you have a dominant defense or league-leading kicker that you do not want to part with, it is not unreasonable to stash them on your bench if you can release a different member of your squad.
Contrary to popular belief, depending on the strength of a team it may be most beneficial to have all of your starters be on a bye the same week so that every other week is full strength.